Nucleoside reverse transcriptase inhibitors. Abacavir is a guanosine analogue which is phosphorylated to carbovir triphosphate which interferes with HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication. Lamivudine is a cytosine analog. After lamivudine is triphosphorylated, the principle mode of action is inhibition of HIV reverse transcription via viral DNA chain termination; inhibits RNA-dependent DNA polymerase activities of reverse transcriptase.
懷孕分級
常用劑量
成人一天一次，每次一粒。
>12 y/o & Adults: One tablet QD
Dosage Adjustment in Renal Impairment:
Clcr <50 mL/min: Use not recommended
Dosage Adjustment in Hepatic Impairment:
Contraindicated
